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ea0037gp.16.01 | Diabetes and obesity–Clinical obesity and cardiovascular | ECE2015

Suppression of plasma free fatty acid concentrations similarly reduces myocardial lipid content and left ventricular systolic function in type 2 diabetic patients and healthy controls

Wolf Peter , Winhofer Yvonne , Smajis Sabina , Catic Anja , Harreiter Jurgen , Kosi-Trebotic Lana , Trattnig Siegfried , Baumgartner-Parzer Sabina , Luger Anton , Krssak Martin , Krebs Michael

Background: Metabolic inflexibility in T2DM might result in reliance on free fatty acids (FFA) as substrates to maintain myocardial energy metabolism compared to lean and healthy controls. Thus, we investigated the effects of an acute suppression of circulating FFA on myocardial lipid content and left ventricular function in extreme phenotypes.Methods: T2DM patients (age: 56±11a; BMI: 28±3.5 kg/m2; HbA1c: 7.29±0.88%) and nine he...

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Endocrine Abstracts

Suppression of plasma free fatty acid concentrations similarly reduces myocardial lipid content and left ventricular systolic function in type 2 diabetic patients and healthy controls

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